Once the most successful mRNA-based LNP was tested in 3D in vitro models, the fluorescent dye continued to facilitate ...

The mRNA therapeutics industry faces a critical manufacturing challenge that threatens both product safety and commercial viability. Double-stranded RNA (dsRNA) formation during in vitro transcription ...

Imagine a breakthrough in cancer treatment where only malignant cells are targeted, sparing healthy host cells; or patients with abnormal protein synthesis are treated to produce a healthy protein.

A team at Oregon State University has engineered lipid nanoparticles that deliver messenger RNA to lung tumors while ...

Imagine a cancer treatment that precisely targets malignant cells, leaving healthy ones untouched. Consider, also, a cancer treatment that corrects abnormal protein synthesis to produce healthy ...

Advances in mRNA design continue to shape the next generation of therapeutic development. Yet, achieving strong and sustained protein expression remains a persistent challenge across platforms.

Researchers develop a self-regulating mRNA medicine that adjusts protein production based on disease-related signals. A research team from The University of Osaka and Institute of Science Tokyo has ...

Making proteins for research or therapies often starts with cell-line development. In many applications, genetic engineering is used to optimize a cell line for producing high levels of the intended ...

mRNA molecule, illustration. [Kateryna Kon/Science Photo Library/Getty Images] Messenger RNA (mRNA) has already transformed medicine, most notably through COVID‑19 vaccines that taught cells to act as ...

Not all parts of our genetic code are equal, even when they appear to say the same thing. Scientists have discovered that ...