A sum of 921 samples were collected from three independent data sets. We obtained pyroptosis-related genes from both the Molecular Signatures Database and relevant literature sources and used four ...

Identification of Pancreatic Cancer Germline Risk Variants With Effects That Are Modified by Smoking A sum of 921 samples were collected from three independent data sets. We obtained ...

At the onset of diabetic cardiomyopathy, Trdn-as expression increases, which regulates the methylation of Casq2 mRNA mediated by METTL14, thus increasing the stability and expression of Casq2 mRNA.

Scientists at the University of Pittsburgh, together with colleagues at the University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, have identified how a long ...

The polarization of macrophages is crucial in modulating the tumor microenvironment and impacting cancer development. Long noncoding RNAs (lncRNAs) have been identified as key regulators in this ...

"There are thousands of long non-coding RNAs, but, until this study, we didn't know what they did," said Gemma Carvill, the study's corresponding author. One of the things we learned in this study is ...

Contrary to historic understanding of RNA’s longevity in cells, some RNAs can persist in cells throughout the life of an organism. Lead authors, Martin Hetzer, PhD, president of the Institute of ...